Thioredoxin reductase | |
---|---|
Identifiers | |
Symbol | ? |
InterPro | IPR005982 |
PROSITE | PS00573 |
SCOP2 | 1zof / SCOPe / SUPFAM |
Thioredoxin reductases (TR, TrxR) (EC 1.8.1.9) are enzymes that reduce thioredoxin (Trx).[1] Two classes of thioredoxin reductase have been identified: one class in bacteria and some eukaryotes and one in animals. In bacteria TrxR also catalyzes the reduction of glutaredoxin like proteins known as NrdH.[2][3][4] Both classes are flavoproteins which function as homodimers. Each monomer contains a FAD prosthetic group, a NADPH binding domain, and an active site containing a redox-active disulfide bond.[5]
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