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SECIS element

Selenocysteine insertion sequence 1
Predicted secondary structure and sequence conservation of SECIS_1. Letters correspond to the IUPAC notation system for nucleotides.
Identifiers
SymbolSECIS_1
RfamRF00031
Other data
RNA typeCis-reg
Domain(s)Eukaryota
GOGO:0001514
SOSO:1001274
PDB structuresPDBe
Selenocysteine insertion sequence 2
Identifiers
SymbolSECIS_2
RfamRF01988
Other data
Domain(s)Bacteria (seed), Eukaryota (hits)
PDB structuresPDBe
Selenocysteine insertion sequence 3
Identifiers
SymbolSECIS_3
RfamRF01989
Other data
Domain(s)Bacteria (seed), Eukaryota (hits)
PDB structuresPDBe
Selenocysteine insertion sequence 5
Identifiers
SymbolSECIS_4
RfamRF01990
Other data
Domain(s)Bacteria
PDB structuresPDBe
Selenocysteine insertion sequence 5
Identifiers
SymbolSECIS_5
RfamRF01991
Other data
Domain(s)Eukaryota (only Plasmodium)
PDB structuresPDBe

In biology, the SECIS element (SECIS: selenocysteine insertion sequence) is an RNA element around 60 nucleotides in length that adopts a stem-loop structure.[1] This structural motif (pattern of nucleotides) directs the cell to translate UGA codons as selenocysteines (UGA is normally a stop codon). SECIS elements are thus a fundamental aspect of messenger RNAs encoding selenoproteins, proteins that include one or more selenocysteine residues.

  1. ^ Walczak R, Westhof E, Carbon P, Krol A (April 1996). "A novel RNA structural motif in the selenocysteine insertion element of eukaryotic selenoprotein mRNAs". RNA. 2 (4): 367–379. PMC 1369379. PMID 8634917.

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