| Name | Half-Life |
|---|---|
| Collagen | 117 years |
| Eye lens crystallin | >70 years |
| RFC1 | 9 hours |
| RPS8 | 3 hours |
| Ornithine decarboxylase | 11 minutes |
In cell biology, protein turnover refers to the replacement of older proteins as they are broken down within the cell. Different types of proteins have very different turnover rates.
A balance between protein synthesis and protein degradation is required for good health and normal protein metabolism. More synthesis than breakdown indicates an anabolic state that builds lean tissues, more breakdown than synthesis indicates a catabolic state that burns lean tissues. According to D.S. Dunlop, protein turnover occurs in brain cells the same as any other eukaryotic cells, but that "knowledge of those aspects of control and regulation specific or peculiar to brain is an essential element for understanding brain function."[3]
Protein turnover is believed to decrease with age in all senescent organisms including humans. This results in an increase in the amount of damaged protein within the body.
- ^ Toyama BH, Hetzer MW (January 2013). "Protein homeostasis: live long, won't prosper". Nature Reviews. Molecular Cell Biology. 14 (1): 55–61. doi:10.1038/nrm3496. PMC 3570024. PMID 23258296.
- ^ Eden E, Geva-Zatorsky N, Issaeva I, Cohen A, Dekel E, Danon T, et al. (February 2011). "Proteome half-life dynamics in living human cells". Science. 331 (6018): 764–768. Bibcode:2011Sci...331..764E. doi:10.1126/science.1199784. PMID 21233346.
- ^ Dunlop DS (1983). "Protein Turnover in Brain Synthesis and Degradation". Handbook of Neurochemistry. pp. 25–63. doi:10.1007/978-1-4899-4555-6_2. ISBN 978-1-4899-4557-0.
© MMXXIII Rich X Search. We shall prevail. All rights reserved. Rich X Search