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Iron-responsive element-binding protein

Iron Regulatory Protein
Identifiers
SymbolACO1
Alt. symbolsIREB1
NCBI gene48
HGNC117
OMIM100880
RefSeqNM_002197
UniProtP21399
Other data
EC number4.2.1.3
LocusChr. 9 p21.1
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StructuresSwiss-model
DomainsInterPro
iron-responsive element-binding protein 2
Identifiers
SymbolIREB2
NCBI gene3658
HGNC6115
OMIM147582
RefSeqNM_004136
UniProtP48200
Other data
LocusChr. 15 q25.1
Search for
StructuresSwiss-model
DomainsInterPro

The iron-responsive element-binding proteins, also known as IRE-BP, IRBP, IRP and IFR ,[1] bind to iron-responsive elements (IREs) in the regulation of human iron metabolism.[2]

  1. ^ Gray, N. K.; Hentze, M. W. (Aug 1994). "Iron regulatory protein prevents binding of the 43S translation pre-initiation complex to ferritin and eALAS mRNAs". EMBO J. 13 (16): 3882–3891. doi:10.1002/j.1460-2075.1994.tb06699.x. PMC 395301. PMID 8070415.
  2. ^ Eisenstein RS (2000). "Iron regulatory proteins and the molecular control of mammalian iron metabolism". Annu. Rev. Nutr. 20: 627–62. doi:10.1146/annurev.nutr.20.1.627. PMID 10940348.

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