Gasotransmitter

Gasotransmitters is a class of neurotransmitters. The molecules are distinguished from other bioactive endogenous gaseous signaling molecules based on a need to meet distinct characterization criteria. Currently, only nitric oxide, carbon monoxide, and hydrogen sulfide are accepted as gasotransmitters.[1] According to in vitro models, gasotransmitters, like other gaseous signaling molecules, may bind to gasoreceptors and trigger signaling in the cells.[1]

The name gasotransmitter is not intended to suggest a gaseous physical state such as infinitesimally small gas bubbles; the physical state is dissolution in complex body fluids and cytosol.[2] These particular gases share many common features in their production and function but carry on their tasks in unique ways which differ from classical signaling molecules.

  1. ^ a b Mustafa AK, Gadalla MM, Snyder SH (April 2009). "Signaling by gasotransmitters". Science Signaling. 2 (68): re2. doi:10.1126/scisignal.268re2. PMC 2744355. PMID 19401594.
  2. ^ Simpson PV, Schatzschneider U (2014-04-18). "Release of Bioactive Molecules Using Metal Complexes". In Gasser G (ed.). Inorganic Chemical Biology. Chichester, UK: John Wiley & Sons, Ltd. pp. 309–339. doi:10.1002/9781118682975.ch10. ISBN 978-1-118-68297-5.

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