Ferroportin

SLC40A1
Identifiers
Aliases	SLC40A1, IREG1, MST079, MSTP079, solute carrier family 40 member 1, MTP1, SLC11A3, FPN1, HFE4
External IDs	OMIM: 604653; MGI: 1315204; HomoloGene: 40959; GeneCards: SLC40A1; OMA:SLC40A1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	189,583,758 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	45,965,683 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; jejunal mucosa; ; mucosa of ileum; ; germinal epithelium; ; trabecular bone; ; decidua; ; cardiac muscle tissue of right atrium; ; palpebral conjunctiva; ; superficial temporal artery; ; duodenum;
	Top expressed in
	epithelium of small intestine; ; medullary collecting duct; ; stroma of bone marrow; ; duodenum; ; spleen; ; tibiofemoral joint; ; left colon; ; granulocyte; ; liver; ; ileum;
	More reference expression data
	n/a
Gene ontology
Molecular function	ferrous iron transmembrane transporter activity; iron ion transmembrane transporter activity; peptide hormone binding; protein binding; identical protein binding;
Cellular component	cytoplasm; integral component of membrane; membrane; synaptic vesicle; plasma membrane; integral component of plasma membrane; intracellular anatomical structure; basolateral plasma membrane; nucleoplasm; cytosol;
Biological process	iron ion transmembrane transport; lymphocyte homeostasis; spleen trabecula formation; iron ion homeostasis; negative regulation of apoptotic process; ion transport; spleen development; multicellular organismal iron ion homeostasis; iron ion transport; endothelium development; iron ion export across plasma membrane; positive regulation of transcription by RNA polymerase II; cellular iron ion homeostasis; regulation of transcription from RNA polymerase II promoter in response to iron;
	Sources:Amigo / QuickGO
Orthologs
	30061
	53945
	ENSG00000138449
	ENSMUSG00000025993
	Q9NP59
	Q9JHI9
	NM_014585
	NM_016917
	NP_055400
	NP_058613
	Wikidata
View/Edit Human	View/Edit Mouse

Ferroportin-1, also known as solute carrier family 40 member 1 (SLC40A1) or iron-regulated transporter 1 (IREG1), is a protein that in humans is encoded by the SLC40A1 gene.^[5] Ferroportin is a transmembrane protein that transports iron from the inside of a cell to the outside of the cell. Ferroportin is the only known iron exporter.^[6]

After dietary iron is absorbed into the cells of the small intestine, ferroportin allows that iron to be transported out of those cells and into the bloodstream. Fpn also mediates the efflux of iron recycled from macrophages resident in the spleen and liver.^[7]

Ferroportin is regulated by hepcidin, a hormone produced by the liver; hepcidin binds to Fpn and limits its iron-efflux activity, thereby reducing iron delivery to the blood plasma.^[8] Therefore, the interaction between Fpn and hepcidin controls systemic iron homeostasis.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138449 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025993 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, et al. (February 2000). "Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter". Nature. 403 (6771): 776–781. Bibcode:2000Natur.403..776D. doi:10.1038/35001596. PMID 10693807. S2CID 4429026.
^ Ward DM, Kaplan J (September 2012). "Ferroportin-mediated iron transport: expression and regulation". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1823 (9): 1426–1433. doi:10.1016/j.bbamcr.2012.03.004. PMC 3718258. PMID 22440327.
^ Canonne-Hergaux F, Donovan A, Delaby C, Wang HJ, Gros P (January 2006). "Comparative studies of duodenal and macrophage ferroportin proteins". American Journal of Physiology. Gastrointestinal and Liver Physiology. 290 (1): G156–G163. doi:10.1152/ajpgi.00227.2005. PMID 16081760.
^ Cite error: The named reference pmid15514116 was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138449 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025993 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Donovan_2000-5] Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, et al. (February 2000). "Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter". Nature. 403 (6771): 776–781. Bibcode:2000Natur.403..776D. doi:10.1038/35001596. PMID 10693807. S2CID 4429026.

[6] Ward DM, Kaplan J (September 2012). "Ferroportin-mediated iron transport: expression and regulation". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1823 (9): 1426–1433. doi:10.1016/j.bbamcr.2012.03.004. PMC 3718258. PMID 22440327.

[7] Canonne-Hergaux F, Donovan A, Delaby C, Wang HJ, Gros P (January 2006). "Comparative studies of duodenal and macrophage ferroportin proteins". American Journal of Physiology. Gastrointestinal and Liver Physiology. 290 (1): G156–G163. doi:10.1152/ajpgi.00227.2005. PMID 16081760.

[pmid15514116-8] Cite error: The named reference pmid15514116 was invoked but never defined (see the help page).

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