Beta sheet

Three-dimensional structure of parts of a beta sheet in green fluorescent protein
Protein secondary structureBeta sheetAlpha helix
The image above contains clickable links
The image above contains clickable links
Interactive diagram of hydrogen bonds in protein secondary structure. Cartoon above, atoms below with nitrogen in blue, oxygen in red (PDB: 1AXC​​)

The beta sheet (β-sheet, also β-pleated sheet) is a common motif of the regular protein secondary structure. Beta sheets consist of beta strands (β-strands) connected laterally by at least two or three backbone hydrogen bonds, forming a generally twisted, pleated sheet. A β-strand is a stretch of polypeptide chain typically 3 to 10 amino acids long with backbone in an extended conformation. The supramolecular association of β-sheets has been implicated in the formation of the fibrils and protein aggregates observed in amyloidosis, Alzheimer's disease and other proteinopathies.


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