Compound that inhibits the oxidation of other molecules
Structure of the antioxidant glutathione
Antioxidants are compounds that inhibit oxidation , a chemical reaction that can produce free radicals . Autoxidation leads to degradation of organic compounds, including living matter.[ 1] Antioxidants are frequently added to industrial products, such as polymers , fuels , and lubricants , to extend their usable lifetimes.[ 2] Foods are also treated with antioxidants to prevent spoilage , in particular the rancidification of oils and fats . In cells , antioxidants such as glutathione , mycothiol , or bacillithiol , and enzyme systems like superoxide dismutase inhibit damage from oxidative stress .[ 3] [ 4]
Known dietary antioxidants are vitamins A , C , and E , but the term has also been applied to various compounds that exhibit antioxidant properties in vitro , having little evidence for antioxidant properties in vivo .[ 5] [ 6] [ 7] Dietary supplements marketed as antioxidants have not been shown to maintain health or prevent disease in humans.[ 5] [ 6] [ 7] [ 8]
^ Helberg, Julian; Pratt, Derek A. (2021). "Autoxidation vs. Antioxidants – the fight for forever". Chemical Society Reviews . 50 (13): 7343– 7358. doi :10.1039/D1CS00265A . PMID 34037013 . S2CID 235200305 .
^ Klemchuk, Peter P. (2000). "Antioxidants". Ullmann's Encyclopedia of Industrial Chemistry . doi :10.1002/14356007.a03_091 . ISBN 3527306730 .
^ Fang, Yun-Zhong; Yang, Sheng; Wu, Guoyao (2002). "Free radicals, antioxidants, and nutrition". Nutrition . 18 (10): 872– 879. doi :10.1016/s0899-9007(02)00916-4 . PMID 12361782 .
^ Zehiroglu, Cuma; Ozturk Sarikaya, Sevim Beyza (November 2019). "The importance of antioxidants and place in today's scientific and technological studies" . Journal of Food Science and Technology . 56 (11): 4757– 4774. doi :10.1007/s13197-019-03952-x . ISSN 0022-1155 . PMC 6828919 . PMID 31741500 .
^ a b "Antioxidant Supplements: What You Need To Know" . National Center for Complementary and Integrative Health, US National Institutes of Health. July 2023. Retrieved 23 April 2025 .
^ a b Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C (14 March 2012). "Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases" . The Cochrane Database of Systematic Reviews . 2012 (3): CD007176. doi :10.1002/14651858.CD007176.pub2 . hdl :10138/136201 . PMC 8407395 . PMID 22419320 .
^ a b O'Connor EA, Evans CV, Ivlev I, Rushkin MC, Thomas RG, Martin A, Lin JS (June 2022). "Vitamin and Mineral Supplements for the Primary Prevention of Cardiovascular Disease and Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force" . JAMA . 327 (23): 2334– 2347. doi :10.1001/jama.2021.15650 . PMID 35727272 .
^ Myung SK, Ju W, Cho B, Oh SW, Park SM, Koo BK, Park BJ (January 2013). "Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials" . BMJ - Clinical Research . 346 : f10. doi :10.1136/bmj.f10 . PMC 3548618 . PMID 23335472 .