Antioxidant

Structure of the antioxidant glutathione

Antioxidants are compounds that inhibit oxidation, a chemical reaction that can produce free radicals. Autoxidation leads to degradation of organic compounds, including living matter.[1] Antioxidants are frequently added to industrial products, such as polymers, fuels, and lubricants, to extend their usable lifetimes.[2] Foods are also treated with antioxidants to prevent spoilage, in particular the rancidification of oils and fats. In cells, antioxidants such as glutathione, mycothiol, or bacillithiol, and enzyme systems like superoxide dismutase inhibit damage from oxidative stress.[3][4]

Known dietary antioxidants are vitamins A, C, and E, but the term has also been applied to various compounds that exhibit antioxidant properties in vitro, having little evidence for antioxidant properties in vivo.[5][6][7] Dietary supplements marketed as antioxidants have not been shown to maintain health or prevent disease in humans.[5][6][7][8]

  1. ^ Helberg, Julian; Pratt, Derek A. (2021). "Autoxidation vs. Antioxidants – the fight for forever". Chemical Society Reviews. 50 (13): 7343–7358. doi:10.1039/D1CS00265A. PMID 34037013. S2CID 235200305.
  2. ^ Klemchuk, Peter P. (2000). "Antioxidants". Ullmann's Encyclopedia of Industrial Chemistry. doi:10.1002/14356007.a03_091. ISBN 3527306730.
  3. ^ Fang, Yun-Zhong; Yang, Sheng; Wu, Guoyao (2002). "Free radicals, antioxidants, and nutrition". Nutrition. 18 (10): 872–879. doi:10.1016/s0899-9007(02)00916-4. PMID 12361782.
  4. ^ Zehiroglu, Cuma; Ozturk Sarikaya, Sevim Beyza (November 2019). "The importance of antioxidants and place in today's scientific and technological studies". Journal of Food Science and Technology. 56 (11): 4757–4774. doi:10.1007/s13197-019-03952-x. ISSN 0022-1155. PMC 6828919. PMID 31741500.
  5. ^ a b "Antioxidant Supplements: What You Need To Know". National Center for Complementary and Integrative Health, US National Institutes of Health. July 2023. Retrieved 23 April 2025.
  6. ^ a b Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C (14 March 2012). "Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases". The Cochrane Database of Systematic Reviews. 2012 (3): CD007176. doi:10.1002/14651858.CD007176.pub2. hdl:10138/136201. PMC 8407395. PMID 22419320.
  7. ^ a b O'Connor EA, Evans CV, Ivlev I, Rushkin MC, Thomas RG, Martin A, Lin JS (June 2022). "Vitamin and Mineral Supplements for the Primary Prevention of Cardiovascular Disease and Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force". JAMA. 327 (23): 2334–2347. doi:10.1001/jama.2021.15650. PMID 35727272.
  8. ^ Myung SK, Ju W, Cho B, Oh SW, Park SM, Koo BK, Park BJ (January 2013). "Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials". BMJ - Clinical Research. 346: f10. doi:10.1136/bmj.f10. PMC 3548618. PMID 23335472.

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